How tiny innovations
inspired huge opportunities.

Novel Nanotopography

Novel Nanotechnology

The revolutionary nanotopography of Sofusa™ has been shown by in vitro studies to perturbate the extracellular matrix, enabling drug flow through tight cellular junctions.

Lymphatic Targeting

Lymphatic Targeting

With proprietary microneedle technology, the Sofusa™ platform is designed to access lymphatic capillaries just below the epidermis.

Tunable Distribution

Tunable Distribution

The Sofusa™ proprietary distributor block is adaptable to a range of pharmacokinetic requirements and helps ensure precise, consistent drug flow through the microneedle array.

Sofusa™ does what subcutaneous injections can never do.

MFB = Microneedle Fluidic Block

Advantaged Lymphatic Absorption

Nanotopography draped microneedles infuse drug within the epidermis to access both the systemic and lymphatic capillaries. This creates an efficient mass transfer system and helps to avoid the inherent inefficiencies of subcutaneous drug delivery.

Tunable Pharmacokinetics

The Sofusa™ platform can be tuned to deliver controllable, consistent drug flow with potential to enable superior efficacy and fewer adverse events.

Technical Reference Materials

The Effect of Nanotopography on Modulating Protein Adsorption and the Fibrotic Response

The Effect of Nanotopography on Modulating Protein Adsorption and the Fibrotic Response

Kam, K.R., Walsh, L. A., Bock, S., Ollerenshaw, J., Ross, R.F., Desai, T.A.; “The Effect of Nanotopography on Modulating Protein Adsorption and the Fibrotic Response,” Tissue Engineering, Vol. 00/Num. 00; 2013.

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Nanotopography Facilitates in Vivo Transdermal Delivery of High Molecular Weight Therapeutics through an Integrin-Dependent Mechanism

Nanotopography Facilitates in Vivo Transdermal Delivery of High Molecular Weight Therapeutics through an Integrin-Dependent Mechanism

Walsh, L., Ryu, J., Bock, S., Koval, M., Mauro, T., Ross, R., Desai, T. “Nanotopography Facilitates in Vivo Transdermal Delivery of High Molecular Weight Therapeutics through an Integrin-Dependent Mechanism,” Nano Letters, 2434-2441, 2015.

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Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography

Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography

Kam, K.R., Walsh, L. A., Bock, S., Koval, M., Fischer, K.E., Ross, R.F., Desai, T.A.; “Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography,” Nano Letters, Vol. 13, 164-171, 2013.

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Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis

Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis

Melissa B. Aldrich, Fred C. Velasquez, Sunkuk Kwon, Ali Azhdarinia, Kenneth Pinkston, Barrett R. Harvey, Wenyaw Chan, John C. Rasmussen, Russell F. Ross, Caroline E. Fife and E. M. Sevick-Muraca; "Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis," Arthritis Research & Therapy, 19:116, 2017

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